Development of an antibacterial porous scaffold for bone defect treatment

Background & Aim: The use of bone scaffolds is one of the new and efficient techniques for repairing bone defects that provide a suitable platform for cell proliferation and growth to repair the target tissue. One of the most important causes of failure of transplants and surgical procedures is the invasion of bacteria at the site of the complication and the development of severe infection. The purpose of this study, which was carried out at the Faculty of New Sciences and Technologies, University of Tehran at 2017-2019, Antibacterial Properties of Porous Scaffolds Made of Gelatin, Calcium Phosphate Zeolite with Loading of Clindamycin. Material and methods: In this study, freeze-drying was made from a combination of gelatin, calcium phosphate, and natural zeolite of bone tissue scaffolds and then the drug was loaded with different amounts of clindamycin. The surface of the scaffold was examined by scanning electron microscopy and antibacterial test and drug release test were performed on the scaffold. Results: The results showed that the aforementioned composite scaffold did not induce growth inhibition in the antibacterial test, However, after loading the drug on the scaffold with a concentration of 0.01 drug, the growth zone was 2 and 4 mm in diameter for Escherichia coli and Staphylococcus aureus, respectively. Conclusions: Addition of the antibacterial agent clindamycin to the bone scaffold made a suitable substrate for drug delivery to bone tissue at the site of removal has been removed to prevent the growth of infection at the scaffold implant during the first period of repair.